MovDisordV3, Main, Exploration, bibRecord, 003736

Serum from Sydenham's chorea patients modifies intracellular calcium levels in PC12 cells by a complement‐independent mechanism

Identifieur interne : 003736 ( Main/Exploration ); précédent : 003735; suivant : 003737

Serum from Sydenham's chorea patients modifies intracellular calcium levels in PC12 cells by a complement‐independent mechanism

Auteurs : Antonio L. Teixeira Jr [Brésil] ; Melissa M. Guimarães [Brésil] ; Marco Aurélio Romano-Silva [Brésil] ; Francisco Cardoso [Brésil]

Source :

Movement Disorders [ 0885-3185 ] ; 2005-07.

RBID : ISTEX:F6E76324CDD028F50548213052BBA250789A1002

English descriptors

KwdEn :
- Adolescent, Animals, Antibodies (pharmacology), Basal Ganglia (immunology), Ca2+, Calcium (metabolism), Child, Chorea (blood), Chorea (immunology), Complement System Proteins (pharmacology), Enzyme-Linked Immunosorbent Assay (methods), Female, Humans, Intracellular Fluid (metabolism), Microscopy, Confocal (methods), PC12 Cells (drug effects), PC12 cells, Potassium Chloride (pharmacology), Rats, Serum (metabolism), Sydenham's chorea, antibasal ganglia antibodies, streptococcus.
MESH :
- chemical , metabolism : Calcium.
- chemical , pharmacology : Antibodies, Complement System Proteins, Potassium Chloride.
- blood : Chorea.
- drug effects : PC12 Cells.
- immunology : Basal Ganglia, Chorea.
- metabolism : Intracellular Fluid, Serum.
- methods : Enzyme-Linked Immunosorbent Assay, Microscopy, Confocal.
- Adolescent, Animals, Child, Female, Humans, Rats.

Abstract

The proposed pathogenesis of Sydenham's chorea (SC) is an autoantibody‐mediated basal ganglia dysfunction. Our study has shown that incubation of PC12 cells with complement‐inactivated serum from SC patients was associated with a significant increase in Ca2+ levels evoked by KCl stimulus (mean ± SEM, 341.0 ± 8.7% of fluorescence intensity, arbitrary units) when compared with incubation with control serum (313.8 ± 8.7% of fluorescence intensity, arbitrary units; P = 0.01). The increase in Ca2+ levels determined by SC patients sera correlated directly with the enzyme‐linked immunosorbent assay optical density values for anti–basal ganglia antibodies. Our study supports the hypothesis that antibodies against basal ganglia in SC may cause their dysfunction. © 2005 Movement Disorder Society

Url:

https://api.istex.fr/document/F6E76324CDD028F50548213052BBA250789A1002/fulltext/pdf

DOI: 10.1002/mds.20418

Affiliations:

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Serum from Sydenham's chorea patients modifies intracellular calcium levels in PC12 cells by a complement‐independent mechanism</title>
<author><name sortKey="Teixeira Jr, Antonio L" sort="Teixeira Jr, Antonio L" uniqKey="Teixeira Jr A" first="Antonio L." last="Teixeira Jr">Antonio L. Teixeira Jr</name>
</author>
<author><name sortKey="Guimaraes, Melissa M" sort="Guimaraes, Melissa M" uniqKey="Guimaraes M" first="Melissa M." last="Guimarães">Melissa M. Guimarães</name>
</author>
<author><name sortKey="Romano Ilva, Marco Aurelio" sort="Romano Ilva, Marco Aurelio" uniqKey="Romano Ilva M" first="Marco Aurélio" last="Romano-Silva">Marco Aurélio Romano-Silva</name>
</author>
<author><name sortKey="Cardoso, Francisco" sort="Cardoso, Francisco" uniqKey="Cardoso F" first="Francisco" last="Cardoso">Francisco Cardoso</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:F6E76324CDD028F50548213052BBA250789A1002</idno>
<date when="2005" year="2005">2005</date>
<idno type="doi">10.1002/mds.20418</idno>
<idno type="url">https://api.istex.fr/document/F6E76324CDD028F50548213052BBA250789A1002/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">003518</idno>
<idno type="wicri:Area/Istex/Curation">003518</idno>
<idno type="wicri:Area/Istex/Checkpoint">002142</idno>
<idno type="wicri:doubleKey">0885-3185:2005:Teixeira Jr A:serum:from:sydenham</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:15747354</idno>
<idno type="wicri:Area/PubMed/Corpus">003120</idno>
<idno type="wicri:Area/PubMed/Curation">003120</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002F68</idno>
<idno type="wicri:Area/Ncbi/Merge">001181</idno>
<idno type="wicri:Area/Ncbi/Curation">001181</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001181</idno>
<idno type="wicri:doubleKey">0885-3185:2005:Teixeira A:serum:from:sydenham</idno>
<idno type="wicri:Area/Main/Merge">004E19</idno>
<idno type="wicri:Area/Main/Curation">003736</idno>
<idno type="wicri:Area/Main/Exploration">003736</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Serum from Sydenham's chorea patients modifies intracellular calcium levels in PC12 cells by a complement‐independent mechanism</title>
<author><name sortKey="Teixeira Jr, Antonio L" sort="Teixeira Jr, Antonio L" uniqKey="Teixeira Jr A" first="Antonio L." last="Teixeira Jr">Antonio L. Teixeira Jr</name>
<affiliation wicri:level="4"><country xml:lang="fr">Brésil</country>
<wicri:regionArea>Movement Disorders Clinic, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte</wicri:regionArea>
<placeName><settlement type="city">Belo Horizonte</settlement>
<region type="state">Minas Gerais</region>
</placeName>
<orgName type="university">Université fédérale du Minas Gerais</orgName>
</affiliation>
</author>
<author><name sortKey="Guimaraes, Melissa M" sort="Guimaraes, Melissa M" uniqKey="Guimaraes M" first="Melissa M." last="Guimarães">Melissa M. Guimarães</name>
<affiliation wicri:level="4"><country xml:lang="fr">Brésil</country>
<wicri:regionArea>Laboratory of Neuropharmacology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte</wicri:regionArea>
<placeName><settlement type="city">Belo Horizonte</settlement>
<region type="state">Minas Gerais</region>
</placeName>
<orgName type="university">Université fédérale du Minas Gerais</orgName>
</affiliation>
</author>
<author><name sortKey="Romano Ilva, Marco Aurelio" sort="Romano Ilva, Marco Aurelio" uniqKey="Romano Ilva M" first="Marco Aurélio" last="Romano-Silva">Marco Aurélio Romano-Silva</name>
<affiliation wicri:level="4"><country xml:lang="fr">Brésil</country>
<wicri:regionArea>Laboratory of Neuropharmacology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte</wicri:regionArea>
<placeName><settlement type="city">Belo Horizonte</settlement>
<region type="state">Minas Gerais</region>
</placeName>
<orgName type="university">Université fédérale du Minas Gerais</orgName>
</affiliation>
</author>
<author><name sortKey="Cardoso, Francisco" sort="Cardoso, Francisco" uniqKey="Cardoso F" first="Francisco" last="Cardoso">Francisco Cardoso</name>
<affiliation wicri:level="4"><country xml:lang="fr">Brésil</country>
<wicri:regionArea>Movement Disorders Clinic, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte</wicri:regionArea>
<placeName><settlement type="city">Belo Horizonte</settlement>
<region type="state">Minas Gerais</region>
</placeName>
<orgName type="university">Université fédérale du Minas Gerais</orgName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2005-07">2005-07</date>
<biblScope unit="vol">20</biblScope>
<biblScope unit="issue">7</biblScope>
<biblScope unit="page" from="843">843</biblScope>
<biblScope unit="page" to="845">845</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">F6E76324CDD028F50548213052BBA250789A1002</idno>
<idno type="DOI">10.1002/mds.20418</idno>
<idno type="ArticleID">MDS20418</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Animals</term>
<term>Antibodies (pharmacology)</term>
<term>Basal Ganglia (immunology)</term>
<term>Ca2+</term>
<term>Calcium (metabolism)</term>
<term>Child</term>
<term>Chorea (blood)</term>
<term>Chorea (immunology)</term>
<term>Complement System Proteins (pharmacology)</term>
<term>Enzyme-Linked Immunosorbent Assay (methods)</term>
<term>Female</term>
<term>Humans</term>
<term>Intracellular Fluid (metabolism)</term>
<term>Microscopy, Confocal (methods)</term>
<term>PC12 Cells (drug effects)</term>
<term>PC12 cells</term>
<term>Potassium Chloride (pharmacology)</term>
<term>Rats</term>
<term>Serum (metabolism)</term>
<term>Sydenham's chorea</term>
<term>antibasal ganglia antibodies</term>
<term>streptococcus</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Calcium</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antibodies</term>
<term>Complement System Proteins</term>
<term>Potassium Chloride</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Chorea</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>PC12 Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Basal Ganglia</term>
<term>Chorea</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Intracellular Fluid</term>
<term>Serum</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Enzyme-Linked Immunosorbent Assay</term>
<term>Microscopy, Confocal</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Animals</term>
<term>Child</term>
<term>Female</term>
<term>Humans</term>
<term>Rats</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The proposed pathogenesis of Sydenham's chorea (SC) is an autoantibody‐mediated basal ganglia dysfunction. Our study has shown that incubation of PC12 cells with complement‐inactivated serum from SC patients was associated with a significant increase in Ca2+ levels evoked by KCl stimulus (mean ± SEM, 341.0 ± 8.7% of fluorescence intensity, arbitrary units) when compared with incubation with control serum (313.8 ± 8.7% of fluorescence intensity, arbitrary units; P = 0.01). The increase in Ca2+ levels determined by SC patients sera correlated directly with the enzyme‐linked immunosorbent assay optical density values for anti–basal ganglia antibodies. Our study supports the hypothesis that antibodies against basal ganglia in SC may cause their dysfunction. © 2005 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>Brésil</li>
</country>
<region><li>Minas Gerais</li>
</region>
<settlement><li>Belo Horizonte</li>
</settlement>
<orgName><li>Université fédérale du Minas Gerais</li>
</orgName>
</list>
<tree><country name="Brésil"><region name="Minas Gerais"><name sortKey="Teixeira Jr, Antonio L" sort="Teixeira Jr, Antonio L" uniqKey="Teixeira Jr A" first="Antonio L." last="Teixeira Jr">Antonio L. Teixeira Jr</name>
</region>
<name sortKey="Cardoso, Francisco" sort="Cardoso, Francisco" uniqKey="Cardoso F" first="Francisco" last="Cardoso">Francisco Cardoso</name>
<name sortKey="Guimaraes, Melissa M" sort="Guimaraes, Melissa M" uniqKey="Guimaraes M" first="Melissa M." last="Guimarães">Melissa M. Guimarães</name>
<name sortKey="Romano Ilva, Marco Aurelio" sort="Romano Ilva, Marco Aurelio" uniqKey="Romano Ilva M" first="Marco Aurélio" last="Romano-Silva">Marco Aurélio Romano-Silva</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003736 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003736 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:F6E76324CDD028F50548213052BBA250789A1002
   |texte=   Serum from Sydenham's chorea patients modifies intracellular calcium levels in PC12 cells by a complement‐independent mechanism
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

Movement Disorders (revue)

Serum from Sydenham's chorea patients modifies intracellular calcium levels in PC12 cells by a complement‐independent mechanism

Serum from Sydenham's chorea patients modifies intracellular calcium levels in PC12 cells by a complement‐independent mechanism

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.